Subgrouping Chronic Fatigue Syndrome Patients By Genetic and Immune Profiling
Abstract
We have successfully performed all testing of the approximately 600 samples (200 CFS/ME patients vs 397 healthy controls) we set up to do under this grant at the Stanford Human Immune Monitoring Center (HIMC) and the Stanford HLA Mindrinos lab. These samples were tested by two novel methods (CyTOF-phosphoflow and HLA Typing, respectively) to help us better understand the roles of immune responses and genetics in the pathogenesis of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME). It is likely that these findings will also result in an improved understanding of the pathogenesis of Gulf War Illness(GWI). For both methods, CyTOF-phosphoflow and HLA Typing, we have reviewed in excruciating detail all the potential sources of technical error in both methods, systematically cleaned all confounders and plate effects, and have set up a statistical plan.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2015
- Accession Number
- AD1007412
Entities
People
- Donn Gavert
- Holden Maecker
- Jose Montoya
- Luciana Mendiola
- Michael Mindrinos
- Rosemary Fernandez
- Tyson Holmes
Organizations
- Stanford University