Androgen Deprivation Enhances PLZF-Repressed Cistrome that Promotes the Castration-Resistant Phenotype

Abstract

Androgen deprivation therapy (ADT) is an important therapeutic strategy which has a fundamental impact on prostate cancer biology. However, the mechanism by which ADT influences this negative androgenic regulation in CRPC development is unclear. Here, I identified an androgen-inducible tumor suppressor, Promyelocytic leukemia zinc finger protein (PLZF) which plays different roles in growth control, senescence, self-renewal, and tumor suppression in various cancer types. Interestingly, PLZF was reported as an androgen-responsive gene with anti-proliferative activity in prostate cancer cells. Moreover, decreased PLZF gene expression was observed in CRPC as compared to primary tumors, suggesting that loss of PLZF expression may have a role on CRPC development.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1007417

Entities

People

  • Chen-lin Hsieh

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biology
  • Castration
  • Deprivation
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Genetics
  • Leukemia
  • Medical Personnel
  • Neoplasms
  • Phenotypes
  • Prostate
  • Prostate Cancer
  • Regulations
  • Suppressors

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.