Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)

Abstract

This 3 year multi-site project is now complete. It has successfully studied the role of toll like receptor 4 in both opioid and cocaine reward / reinforcement. In addition it has successfully documented the potential of ( )naltrexone (a clinically relevant, blood brain barrier permeable, non-opioid toll like receptor 4antagonist) as an inhibitor of the rewarding / reinforcing effects of cocaine and opioids. Notably, it suppresses reinstatement to drug seeking (relapse)supportive of the interest in this compound for aiding drug abusers in the goal of avoiding relapse. In exploring brain mechanisms underlying these effects, we have accrued evidence supportive of both nucleus accumbens and ventral tegmental nucleus involvement.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1007485

Entities

People

  • Jonathan Katz
  • Linda R. Watkins
  • Ryan Bachtell
  • Steven Maier

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Blood-Brain Barrier
  • Brain
  • Cells
  • Chemistry
  • Drug Abuse
  • Drug Addiction
  • Inhibitors
  • Nervous System
  • Neuroglia
  • Neurons
  • Neurosciences
  • Opioids
  • Pain
  • Surgery
  • Therapy
  • Veins

Fields of Study

  • Biology
  • Psychology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.