Role of microRNA in Aggressive Prostate Cancer
Abstract
The majority of mortality of prostate cancer (PCa) is due to the recurrent metastasized castration resistance PCa. The acquisition of epithelialto-mesenchymal transition (EMT) in PCa signifies the initial process of cancer metastasis. Our previous findings unveiled that DAB2IP is down-regulated in high-grade PCa specimens and this novel tumor suppressor can block EMT leading to lymph node metastasis. It has recently been associated with the onset of cancer stem cell (CSC) that is considered as cancer initiating cell with a survival advantage during the course of cancer therapy. However, the mechanism of action is not fully characterized. Using microRNA microarray screening, we found microRNA-363 (miR363) is significantly down regulated in several DAB2IP knockdown (KD) prostate cells. In particular, miR363 is predominately expressed in normal prostate and belongs to the miR106a-363 cluster that is closely resembled to the oncogenic miR17-92 cluster in their seed sequence. It appears that DAB2IP significantly regulates the expression of a unique miR-363; the profile of miR-363 expression appears to be highly specific in normal prostate. The objective of this project is to delineate the functional links of miR-363 with the appearance of CSC and its clinical correlation in aggressive PCa.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2015
- Accession Number
- AD1007582
Entities
People
- Jer-Tsong Hsieh
Organizations
- University of Texas at Austin