Clinical Characterization and Imaging of Triggered Attacks in Chronic Migraine and Posttraumatic Headache
Abstract
Chronic posttraumatic headache (PTH) is a disabling disorder that affects millions of individuals worldwide. The Principal Investigators (PIs) of this application proposed to develop human models of PTH by characterizing clinical features and correlated changes in brain activity before and during triggered attacks. The PIs hypothesized that the different headache triggers nitroglycerin (NTG) and prostaglandin E2 (PGE2) would produce different types of headache and would be associated with different patterns of brain metabolism that would reveal fundamental mechanisms of PTH. The studies were submitted for and achieved IRB approval at UCLA, and plans were in place to begin subject recruitment for the studies. However, because of administrative issues at UCSF (Dr. Goadsbys move leading to a change to a part-time appointment there), and because of an unexpected inability to obtain pharmaceutical grade PGE2, the actual research studies were not initiated, and the study has now been terminated. We are in the process of establishing a collaboration between UCLA and Kings College London (the location of Dr. Goadsbys new position) and plan to move ahead with a similar but revised study once this formal collaboration is established. We will therefore continue to pursue the goals of this study in the future, but at this time the study is terminated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2016
- Accession Number
- AD1007599
Entities
People
- Andrew Charles
- Peter Goadsby
Organizations
- University of Southern California