Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse

Abstract

The purpose of this work is to utilize monocyte/macrophage-enabled delivery, a novel therapeutic delivery system that we pioneered, to increase the effectiveness and decrease thetoxicity of the treatment of intracranial metastases from primary breast cancer. Our objective in this proposal is to deliver therapeutics to brain metastases using a nanoshell(NS)-double-stranded DNA (dsDNA)-drug complex loaded within monocytes/macrophages. Once present within the metastasis, we aim to release the drug by transcranial irradiation atnear-infrared (NIR) wavelengths. Our studies have provided fundamental information on a number of aspects of the delivery of therapeutics by NSdsDNA.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1007726

Entities

People

  • Amanda Goodman
  • Keith Stantz
  • Naomi J. Halas
  • Susan Clare

Organizations

  • Rice University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Blood-Brain Barrier
  • Breast Cancer
  • Cancer
  • Central Nervous System
  • Electro-Optics
  • Health Services
  • Measurement
  • Metallic Nanoparticles
  • Monte Carlo Method
  • Near Infrared Radiation
  • Optical Properties
  • Optics
  • Refractive Index
  • Therapy
  • Three Dimensional
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Military Engineering.
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology and Biomarker-Based Cancer Detection.