Biological and Clinical Characterization of Novel lncRNAs Associated with Metastatic Prostate Cancer
Abstract
Despite improvements in medical treatments over the past three decades, prostate cancer remains the second most common cause of cancer related deaths among U.S. men. According to National Cancer Institute, in 2012 ~241,000 prostate cancer diagnosis and ~28,000 related deaths of American men were estimated. Androgen deprivation, surgery, and/or radiotherapy in combination with chemotherapy has proven to be effective in treating patients that display localized disease; however, progression to hormone refractory aggressive disease in a subset of prostate cancer patients remains the primary cause of mortality. The molecular mechanisms that contribute to the progression of localized disease into an aggressive disease remain largely unknown. Long non-coding RNAs (lncRNAs) have recently emerged as key players in tumor biology and can potentially serve as promising biomarkers. However, the vast majority of lncRNAs remain undiscovered or uncharacterized entities and their roles in prostate cancer are unclear.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2015
- Accession Number
- AD1007754
Entities
People
- Rohit Malik
Organizations
- Board of Regents of the University of Michigan