Inflammation Modulatory Protein TSG-6 for Chemical Injuries to the Cornea

Abstract

During this study period we established the time sequence of inflammation, and the cellular and molecular changes which occur after exposure of rat corneas to different concentrations of alkali. These findings set the conditions for testing the effectiveness of both topically applied and intraocular TSG-6, an anti-inflammatory protein, in the promotion of corneal healing and restoration after injury. We found that TSG-6 applied in this manner did not provide a statistically significant benefit to the cornea after alkali injury as evaluated by corneal clarity and by biochemical markers of inflammation. Experiments to test the effectiveness of intravenous TSG-6 are in the preliminary stages.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1007866

Entities

People

  • Samuel Fulcher

Organizations

  • Tempva Research Group Inc.

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DTIC Thesaurus Topics

  • Cell Line
  • Cells
  • Cornea
  • Corneal Diseases
  • Eye
  • Eye Diseases
  • Filter Paper
  • Health Care
  • Health Services
  • Inflammation
  • Ophthalmology
  • Regenerative Medicine
  • Research Facilities
  • Veterans Health

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