7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities

Abstract

We present the second annual report for this project. We have developed and deployed a quantitative MRI set of MRI scans at 7T in healthy volunteers and patients with MS, developed an analysis pipeline and QA for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitter/protein accumulation. All quantitative acquisitions have been evaluated for reproducibility. Behavioral testing shows significant differences between MS and healthy volunteers, along with fMRI, and CEST acquisitions. Analysis hurdles were noted in the qMT, which we discuss here. Recruitment continues in the MS cohort (all healthy subjects have been recruited) during the EWOF. Correlation analysis have been examined, and a translation to lower field strength has generated many further outcomes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1007943

Entities

People

  • Seth A. Smith

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Brain
  • Central Nervous System
  • Cognitive Impairment
  • Computer Vision
  • Department Of Defense
  • High Resolution
  • Information Science
  • Magnetization
  • Multiple Sclerosis
  • Pipelines
  • Reliability
  • Reproducibility
  • Saturation
  • Spinal Cord
  • Test And Evaluation
  • Volunteers

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Medical Imaging.