Early Diagnosis of Clear Cell Kidney Cancer via VHL/HIF Pathway-Regulated Circulating microRNA

Abstract

The over-arching objective of this research project is to identify a panel of diagnostic miRNAs that are measurable in serum and will be able to identify kidney cancer in its earliest stages. We hypothesized that serum levels of miR-21O would be significantly elevated in patients with clear cell renal carcinoma and that a panel of serum miRNAs could be defined and optimized for use as a diagnostic tool in patients presenting with a renal mass. To achieve this objective, we proposed three Specific Aims to test our hypotheses. Institutional IRB approvals have been obtained (Specific Aim 1, task 1). Retrospectively collected samples have been transferred and analyzed (Specific Aim 1, task 3). Prospective sample collection has begun (Specific Aim 3, task 1). Milestones are on track, and we do not anticipate any alterations to our SOW.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
AD1007999

Entities

People

  • Allan J. Pantuck
  • Muneesh Tewari

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • Biomedical Research
  • California
  • Classification
  • Contracts
  • Department Of Defense
  • Electronic Mail
  • Hypotheses
  • Information Operations
  • Kidney Cancer
  • Maryland
  • Monitoring
  • Security
  • Universities

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Trauma or Military Medicine