ETS Gene Fusions as Predictive Biomarkers of Resistance to Radiation Therapy for Prostate Cancer

Abstract

The research goals of this grant proposal are to: 1) investigate the effect of ETS gene fusions on radiation phenotype in preclinical models of prostate cancer, 2) to explore the mechanism of interaction between ERG (the predominant ETS gene fusion product) and the DNA repair protein DNA-PK, and 3) to determine if ETS gene fusion status is a clinical biomarker ofradio resistance for prostate cancer. The training goals of this grant proposal included a series of regular meetings with mentors, research seminars, journal clubs, and workshops, all of which are intended to help Dr. Feng develop as a translational scientist. This grant proposal was approved as a five-year award; the current annual report summarizesaccomplishments over the first year of the grant, from July 15, 2010 to July 15, 2011.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2011
Accession Number
AD1008253

Entities

People

  • Felix Y. Feng

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Birds
  • Body Weight
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Epithelial Cells
  • Gene Expression
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Radiation Oncology

Readers

  • Academic Conference Management
  • Molecular Biology and Genetics
  • Research Science/Academic Research

Technology Areas

  • Biotechnology