Targeting Ligand-Dependent and Ligand-Independent Androgen Receptor Signaling in Prostate Cancer

Abstract

Last year, we made significant progress in testing over a hundred analogues of our lead compound targeting ligand-dependent androgen receptor signaling in Prostate Cancer. We had overcome problems with solubility, off-target effects, toxicity and formulation. However, on rigorous evaluation, we found that we could not be sure that these agents were targeting specifically the interaction between the androgen receptor and coregulators. Towards this end, we developed a novel in vivo FRET assay, that validated the activity of our compounds in blocking the Androgen receptor interaction with specific coregulators.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1008266

Entities

People

  • Ganesh V Raj

Organizations

  • University of Texas Southwestern Medical Center

Tags

DTIC Thesaurus Topics

  • Amides
  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Macromolecules
  • Molecules
  • Neoplasms
  • Polymers
  • Prostate
  • Prostate Cancer
  • Protein-Protein Interactions
  • Proteins
  • Targeting

Fields of Study

  • Biology
  • Chemistry

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