Quantification of VX Nerve Agent in Various Food Matrices by Solid-Phase Extraction Ultra-Performance Liquid ChromatographyTime-of-Flight Mass Spectrometry
Abstract
Liquid chromatographyelectrospray ionization mass spectrometry with positive-ion modes of operation were used for the trace-level determination of O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) in various food matrices. The mixed-mode cation exchange (MCX) sorbent and Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) methods were used for extraction of VX from food samples. The extraction efficiencies obtained with use of the MCX cartridge and QuEChERS methods were compared, and the results revealed that both methods performed similarly. Various VX concentrations, ranging from 5 to 500 ng/mL, were spiked into food samples. The linear range of quantitation for VX was 1 to 330 ng/mL. The total percent recoveries (and percent relative standard deviations) for VX in various food samples are reported.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2016
- Accession Number
- AD1008299
Entities
People
- Mark D Winemiller
- Sue Y. Bae
Organizations
- Edgewood Chemical Biological Center