Intraosseous Hydroxocobalamin versus Intravenous Hydroxocobalamin Compared to Intraosseous Whole Blood or No Treatment for Hemorrhagic Shock in a Swine Model
Abstract
Objective: Determine if intraosseous (IO) hydroxocobalamin (HOC) can improve systolic blood pressure (SBP) after severe hemorrhagic shock. Method: 36 swine (45-55kg) anesthetized, intubated with continuous monitoring. Controlled hemorrhage of 30 of blood volume over 20 min. Randomized to receive 500mL IO blood, 150mg/kg IO or intravenous (IV) HOC in 180mL saline or no treatment. Monitored for 60 min post treatment. Sample size of 8 animals per group. Results: RMANOVA outcome analysis detected a significant difference between groups(p<0.05). IO whole blood, IO HOC, and IV HOC were similar to each other but significantly different compared to controls regarding SBP, MAP, SVR and heart rate. Differences in SBP and MAP were sustained throughout the experiment. Conclusion: IO HOC improved SBP and MAP compared to no treatment and was similar to IO whole blood and IV HOC in this animal model of severe hemorrhage. Moreover, whereas serum lactate was improving in all treated groups, in was deteriorating in the control group.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 02, 2016
- Accession Number
- AD1008671
Entities
People
- Maria G. Castaneda
- Normalynn Garrett
- Susan M. Boudreau
- Vikhyat S Bebarta
Organizations
- 59th Medical Wing