Trial of Naltrexone and Dextromethorphan for Gulf War Veterans' Illness

Abstract

This research study aims to expand the field of knowledge of Gulf War Illness. The research may provide initial proof of the innovative hypothesis that Gulf War Illness is related to low grade neuron-inflammation, which can be down regulated, by Naltrexone and Dextromethorphan. This is untested but potentially groundbreaking concept that could provide, both an enhanced understanding of, and beneficial treatment for, Gulf War Illnesses. Research at the National Institute of Environmental Health and other facilities has proven that naltrexone and dextromethorphan reduce inflammation in the brain. Clinical trials in humans with low Dextromethorphan have established benefits in syndromes related to Gulf War Illness such as fibromyalgia. We have successfully enrolled 41 subjects in the study, and anticipate obtaining important data by the end of the coming year. A no cost extension has been obtained to complete the study.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2015
Accession Number
AD1008700

Entities

People

  • Allison Mainhart
  • Kori L. Brewer
  • William J. Meggs

Organizations

  • East Carolina University

Tags

DTIC Thesaurus Topics

  • Clinical Trials
  • Data Analysis
  • Diseases And Disorders
  • Drug Abuse
  • Environmental Health
  • Health Services
  • Inflammation
  • Medical Personnel
  • Pain
  • Persian Gulf Syndrome
  • Side Effects
  • Statistical Analysis
  • Therapy

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Research Science/Academic Research