Identification of Prostate Cancer-Specific microDNAs

Abstract

Emerging evidence has suggested that eukaryotic cells can express a special group of extrachromosomal circular DNAs (eccDNAs), called microDNAs. Unlike previously reported eccDNAs, microDNAs are relatively small in length, map to unique DNA sequence, and arise from genes, mostly likely resulting from microdeletions. Since they are usually in a circular form, they are more resistant to exonuclease than linear DNAs and can be stably present in the cells or even possibly in the circulating system. Therefore, overall goal of this application is to determine whether prostate cancer cells express such microDNAs which can be used to serve as valuable biomarkers for prostate cancer diagnosis or prognosis.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2016
Accession Number
AD1008736

Entities

People

  • Yin-Yuan Mo

Organizations

  • University of Mississippi Medical Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Markers
  • Biological Sciences
  • Biomedical Research
  • Cell Line
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Eukaryotes
  • Identification
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Sequences
  • Tissues

Fields of Study

  • Biology

Readers

  • Aerospace Propulsion Engineering.
  • Molecular Genetics
  • Molecular and genetic basis of cancer.