Induction of Food Allergy in Mice by Allergen Inhalation
Abstract
The goal of our project is to use mouse models to determine whether and how inhaling egg white can sensitize for thedevelopment of egg white food allergy. Despite difficulties related to the complicated pregnancy and illness of a keyresearcher, considerable progress has been made: 1) We cannot induce an allergic response to aerosolized egg white, even ifinflammation is induced by aspiration of saline. This suggests that additional stimuli are required to induce an allergic responseby this route. 2) We have shown that egg yolk acts as an adjuvant for the development of allergic lung disease tp egg whiteand induction of food allergy; 3) We have shown that egg yolk adjuvanticity is related to its induction of a cellular biochemicalresponse called the unfolded protein response (UPR) and that the UPR induces epithelial cells to produce 3 cytokines that areessential for the induction of food allergy; and 4) we have shown that neutralization of any one of these 3 cytokines preventsfood allergy induction, while neutralization of all 3 suppresses established food allergy. Additionally, preliminary data show thatin vivo suppression of the UPR with an FDA-approved drug can suppress established food allergy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1009143
Entities
People
- Fred Finkelman