Investigation of Microcavitation-Induced Effects using in Vitro Models for Traumatic Brain Injury

Abstract

The project was focused on the development of in vitro biomimetic systems to examine the impact of microcavitation in the brain tissue. We have successfully designed and validated several biosystems to elucidate quantitatively potential biophysical and molecular mechanisms mediating bioeffects which arise from blast-induced shock waves and subsequently generated microbubbles (i.e., microcavitation). The coupling mechanisms responsible for the bioeffects of microbubbles in brain tissues can now be better understood with detail, and lead to formulation of strategies to reverse some of the observed adverse effects.

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Document Details

Document Type
Technical Report
Publication Date
Aug 25, 2016
Accession Number
AD1009450

Entities

People

  • Michael H Cho

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bioengineering
  • Brain Injuries
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Electronic Mail
  • Eye Diseases
  • Mechanical Properties
  • Mechanics
  • Modulus Of Elasticity
  • Shock Waves
  • Stem Cells
  • Three Dimensional
  • Transducers

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Neurotrauma and Rehabilitation Medicine.
  • Theoretical Analysis.

Technology Areas

  • Biotechnology