A Phase-1 Clinical Trial of a DNA Vaccine for Venezuelan Equine Encephalitis Delivered by Intramuscular or Intradermal Electroporation

Abstract

Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus, which causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no licensed vaccines against VEEV available in the United States. We developed a candidate DNA vaccine expressing the E3-E2-6K-E1 genes of VEEV (pWRG/VEEV) and performed a Phase 1 clinical trial to assess safety, reactogenicity, tolerability, and immunogenicity.

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Document Details

Document Type
Technical Report
Publication Date
May 25, 2016
Accession Number
AD1009502

Entities

People

  • Barry Ellefsen
  • Connie S Schmaljohn
  • Drew Hannaman
  • Lesley C. Dupuy

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Acceptability
  • Biomedical Research
  • Chemistry
  • Colitis
  • Diseases And Disorders
  • Encephalitis
  • Equine Encephalitis
  • Health Services
  • Immunogenicity
  • Infectious Diseases
  • Institutional Review Board
  • Materials
  • Medical Personnel
  • Pain
  • Vaccines
  • Viruses

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology