Combat-Related Heterotopic Ossification: Development of Animal Models for Identifying Mechanisms and Testing Therapeutics

Abstract

HO is occurring at significantly higher frequencies in the current war-wounded population than in civilian populations and it is a common and significant problematic clinical entity for war-wounded patients. The available body of evidence suggests that polytraumatic blast injuries induce HO with high frequency as a result of a combination of systemic and local factors. Prevention of HO through the development of prophylactic treatments would reduce military treatment costs and the pain and suffering of Wounded Warriors. A critical hurdlein our investigation of HO etiology, treatment, and prevention is the absence of a reliable and reproducible small animal model that can be used to characterize combatrelated HO development, identify new prophylactic/therapeutic targets, and test new HO countermeasures.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2015
Accession Number
AD1009873

Entities

People

  • Jonathan A. Forsberg

Tags

DTIC Thesaurus Topics

  • Coinfection
  • Combat Injuries
  • Debridement
  • Health Services
  • Medical Personnel
  • Military Medicine
  • Osteogenesis
  • Therapy
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

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