Toxicology Study No. S.0024589d 15, Human Cell Line Activation Test of the Novel Energetic, 3,4 -Dinitropyrazole (DNP)

Abstract

The novel energetic 3,4-dinitropyrazole (DNP) is under consideration as a replacement for trinitrotoluene (TNT) in explosive formulations. The toxicological properties of DNP are under evaluation as part of this effort. This study assessed the skin sensitization potential of DNP through the human cell line activation test (h-CLAT), an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the elicitation of a skin allergy. 3,4-DNP was found to be a sensitizer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2016
Accession Number
AD1010021

Entities

People

  • Emily N. Reinke

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Albumins
  • Antibodies
  • Army Aviation
  • Cell Line
  • Cells
  • Data Analysis
  • Dilution
  • Engineering
  • European Union
  • Explosives
  • Health
  • Military Research
  • Public Health
  • Range Finding
  • Tissue Culture
  • Tnt

Readers

  • Agricultural Chemistry/Soil Science
  • Immunology
  • Toxicology/Environmental Toxicology