The Role of Cardiovascular Muscle Cell Na+-K+ Pump Activity in the Development and Maintenance of Reduced Renal Mass Hypertension in Rats
Abstract
The mechanism of the elevated systemic arterial pressure in low renin experimental hypertension remains obscure. Recent data suggest that activity of the Na+-K+ pump is decreased in cardiovascular muscle cells of dogs with one-kidney, one wrapped and rats with one-kidney, one clip hypertension (low renin types of hypertension) due to a circulating ouabain-like agent. Because acute suppression of cardiovascular muscle cell Na+-K+ pump activity, by ouabain for example, increases blood vessel responsiveness and causes vasoconstriction, it has been hypothesized that suppressed pump activity may be responsible for development of hypertension In these animals. Additional data indicate that acute extracellular fluid volume expansion in dogs and rats stimulates release of a humoral ouabain-llke factor which suppresses vascular Na+-K+ pump activity. Since the volume status of the hypertensive animals showing decreased pump activity is uncertain, the role of volume in release of ouabain-like factor In these animals is not clear. Therefore, in the present Investigation, a low renin model of hypertension with documented volume expansion (reduced renal mass model) was studied.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 28, 1981
- Accession Number
- AD1010625
Entities
People
- Stephen J. Huot
Organizations
- Uniformed Services University of the Health Sciences