Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness

Abstract

The overall goal of the study is to examine whether altered vitamin D status (as measured by serum metabolites and by functional polymorphisms within genes related to vitamin D transport, metabolism and activity) is associated with increased risk of aggressive prostate cancer, and may explain some of the racial disparity seen in aggressive prostate cancer. All of the project activities as outlined in the Statement of Work Tasks and Milestones are complete. IRB approval was obtained from all local institutions and the DoD HSRRB. The study team participated in regular conference calls to discuss study progress and data collection and analyses throughout the grant period. All assays have been performed and data have been merged and cleaned. Statistical analyses for the main project aims are complete, with additional analyses underway. With the large representation of African Americans in this investigation, the research provides insights into the role of vitamin D in prostate cancer among a chronically underserved population carrying an unequal burden of disease.

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Document Details

Document Type
Technical Report
Publication Date
Dec 29, 2015
Accession Number
AD1010634

Entities

People

  • Susan E Steck

Tags

DTIC Thesaurus Topics

  • African Americans
  • Carrier Proteins
  • Data Analysis
  • Data Science
  • Demography
  • Ethnic Groups
  • Genetic Variation
  • Information Science
  • Institutional Review Board
  • Medical Personnel
  • Minority Groups
  • Neoplasms
  • Prostate Cancer
  • Public Health
  • Statistical Analysis
  • United States
  • Vitamin D

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