Early Treatment in Shock. Addendum

Abstract

This study has rested on two basic hypotheses. The first is that agents given during and (for a short period of time) after resuscitation can favorably influence the response to hemorrhagic shock and injury. The second is that studies of gene response studies, specifically microarray and RT-PCR studies, could be used to assess the response of patients being treated for injuries to such therapeutic agents. To date, both hypotheses have been shown to be true in the animal model. Three therapeutic agents have been identified, of which glutamine appears to be the most suitable for initial use in patients. Initial clinical studies have been carried out to validate these hypotheses in patients, by using glutamine in patients immediately following resuscitation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2012
Accession Number
AD1010641

Entities

People

  • Charles Iii Van Way

Organizations

  • University of Missouri–Kansas City

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics
  • Molecular and Cellular Biology