Early Treatment in Shock

Abstract

This study has rested on two basic hypotheses. The first is that agents given during and (for a short period of time) after resuscitation can favorably influence the response to hemorrhagic shock and injury. The second is that studies of gene response studies, specifically microarray and RT-PCR studies, could be used to assess the response of patients being treated for injuries to such therapeutic agents. To date, both hypotheses have been shown to be true in the animal model. Three therapeutic agents have been identified, to be used during and after resuscitation. Studies are ongoing to validate these hypotheses inpatients, including the use of arginine, glutamine, and allopurinol in patients immediately following resuscitation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
AD1010643

Entities

People

  • Charles Iii Van Way

Organizations

  • University of Missouri–Kansas City

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Fish
  • Health Services
  • Hemorrhagic Shock
  • Intellectual Disability
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Surgery
  • Veins

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.