The Regulation of Blood Flow and Metabolism in Adipose Tissue: Evidence for a Role of Adenosine
Abstract
Adenosine Is proposed as a regulator of blood flow in unstimulated adipose tissue and in tissues in which lipolysis and vasodilatlon have been induced by the intravenous infusion of norepinephrine. Invitro studies have shown adenosine to stimulate glucose transport and to inhibit lipolysis. Experiments were designed to determine whether a cause-and-effect relationship exists between variations in tissue adenosine content and changes in vascular resistance, and whether adenosine regulates metabolism In vitro. Theophylline, an adenosine receptor antagonist, or adenosine deaminase, an enzyme which specifically degrades adenosine, was infused into subcutaneous adipose tissues of dogs in order to attenuate the actions of adenosine. Theophylline or adenosine deaminase was infused into both unstimulated tissues and tissues which later received an intravenous infusion of norepinephrine. Neither intraarterial nor intravenous theophylline antagonized the vascular effect a of exogenous adenosine. Intravenous theophylline did not increase vascular resistance, decrease glucose uptake, or increase lipolysis in unstimulated tissues. No attenuation of the vasodilation caused by norepinephrine was observed. Theophylline did not appear to block the vascular or metabolic effects of endogenous adenosine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 17, 1984
- Accession Number
- AD1010724
Entities
People
- Sharon E. Martin
Organizations
- Uniformed Services University of the Health Sciences