Regulation of the Two Delta Crystallin Genes during Lens Development in the Chicken Embryo

Abstract

Delta-crystallin is the major structural protein in the chicken embryo lens. It is encoded by two very similar genes, delta sub 1 and delta sub 2. During lens development, delta sub 1 mRNA is more abundant than delta sub 2 mRNA and the delta sub 1/delta sub 2 ratio is greater in lens fibers than in lens epithelial cells. Thus, the expression of the two delta-crystallin genes is differentially regulated indifferent regions of the lens (Thomas, et. al., 1990). Although, in vitro transfection studies suggested at regulation might occur at the post-transcriptional level, the mechanism responsible for the different levels of mRNA from these two genes is not known.

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Document Details

Document Type
Technical Report
Publication Date
Aug 22, 1991
Accession Number
AD1011019

Entities

People

  • Xuan Li

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Embryos
  • Epithelial Cells
  • Gel Electrophoresis
  • Gene Expression
  • Medical Personnel
  • Molecular Biology
  • Proteins
  • Rna Stability

Fields of Study

  • Biology

Readers

  • Analytical Mechanics
  • Molecular Genetics
  • Molecular and Cellular Biochemistry