Mechanisms of Selective Induction of Gastric Mucosal Eicosanoids in Response to Potentially Noxious Stimuli
Abstract
Gastric mucosal eicosanoids, such as prostaglandins and leukotrienes, are released in response to injurious agents. Prostaglandins however, have a protective action on the mucosa while leukotrienes have been associated with the production of mucosal damage. Although prostaglandins and leukotrienes are both derived from arachidonic acid, they may be elaborated by different cell types. Hypothesis: exposure of the gastric mucosa to potentially noxious but physiological stimuli involves a selective induction of leukotrienes and prostaglandins. Mucosal leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) generation was evaluated following intragastric administration of an 80 ml load of water (control), acid (50 or 100 mM HCl) or bile salts (5mM). One hour later, mucosal biopsies from the antrum and the fundus were obtained by gastroscopy for histological evaluation and for the ex vivo determination mucosal LTC4 and PGE2. There were no differences in histological scoresamong treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1991
- Accession Number
- AD1011021
Entities
People
- Elizabeth A. Montcalm-mazzilli
Organizations
- Uniformed Services University of the Health Sciences