Injury, inflammation and the emergence of human specific genes
Abstract
In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 12, 2016
- Accession Number
- AD1011221
Entities
People
- Andrew Baird
- Brian P Eliceiri
- Raul Coimbra
- Todd Constantini
Organizations
- UC San Diego School of Medicine