New Epigenetic Therapeutic Intervention for Metastatic Breast Cancer
Abstract
Triple-negative breast cancer (TNBC) distinguishes from other forms of breast cancer in origination and progression. Likely originated from undifferentiated cancer stem cells, TNBC tumor cells possess many epithelial-mesenchymal transition (EMT) characteristics including invasion, resistance to apoptosis, and cancer stem cell-like traits that permit tumor dissemination and growth at distant sites. The Wnt pathways are important for EMT. We recently discovered that Wnt5a and its transcription factor Twist are markedly over-expressed in TNBC but not luminal breast cancer cells. We also discovered that constitutively activated NF-kB in TNBC sustains prolonged activation of pro-inflammatory cytokines, enabling rapid spread (metastasis) of TNBC tumors. Notably, the functions of both transcription factors Twist and NF-kB in gene activation require lysine acetylation, which signs to activate the transcriptional machinery in chromatin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2016
- Accession Number
- AD1011389
Entities
People
- Binhua P. Zhou
Organizations
- University of Kentucky