Targeting Signaling to YAP for the Therapy of NF2

Abstract

The goals of this Application are to utilize our new knowledge of the mechanism by which loss of Merlin induces tumorigenesis to identify small molecule compounds that block YAP/TEAD-dependent transcription by acting at any step of our newly identified pathway, and to test the preclinical efficacy of lead compounds in xenograft models of NF2. During the first year of this grant, we have generated NF2 mutant cell lines expressing two different types of YAP reporters and tested their suitability for high throughput screening.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1011455

Entities

People

  • Filippo G. Giancotti

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Cell Line
  • Cells
  • Lead Compounds
  • Medical Personnel
  • Molecules
  • Neoplasms
  • New York
  • Professional Development
  • Proteins
  • Small Molecules
  • Targeting
  • Technology Transfer
  • Throughput
  • Xenografts

Readers

  • Molecular Genetics
  • Neurological Diseases/Conditions/Disorders
  • Prostate Cancer Biology.