Expression and Characterization of Insulin-Like Growth Factor Binding Proteins (IGFBPs) and IGFBP-2 mRNA in the Developing Chicken Eye
Abstract
The Insulin-Like Growth Factors (IGF-I and -II) are small, -7 kDa, polypeptide hormones present in a variety of embryonic and adult tissues. Accumulating evidence indicates that they play a fundamental role in regulating embryonic growth and differentiation. IGFs are normally found in a complex with specific IGF-Binding Proteins (IGFBPS) of which six different types have been identified. Classically, IGFBPs have been shown to function as carriers of IGF, extending the half life of IGF in the circulation. However, recent evidence indicates that IGFBPs are able to either enhance or inhibit IGF effects on a number of different cell types, depending on the IGFBP. Ocular tissues have been shown to contain all of the components of the IGF system, including several different IGFBPs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 30, 1995
- Accession Number
- AD1011459
Entities
People
- Timothy J. Schoen
Organizations
- Uniformed Services University of the Health Sciences