Modular Bioconjugates to Study Herceptin Resistance: A Structural and Functional Approach

Abstract

During the course of these studies, the method for attachment of antibodies to the exterior surface of bacteriophage MS2 capsids was optimized, and the conjugates were fully characterized by a series of biophysical methods. Furthermore, and most importantly, these conjugates were shown to retain their affinity and specificity for their epitopes, and staining procedures for application to mass cytometry experiments were developed, and a proof of concept experiment has been completed. The results of these studies were recently published.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1011462

Entities

People

  • Adel M. Elsohly

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomolecules
  • Chemical Synthesis
  • Chemistry
  • Confocal Microscopy
  • Leviviridae
  • Liquid Chromatography
  • Mass Spectrometry
  • Materials Science
  • Molecules
  • Neoplasms
  • Organic Chemistry
  • Polymers
  • Proteins
  • United States
  • Viral Structures
  • Viruses

Readers

  • Immunology
  • Molecular Genetics
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology