Characterization of the Virus and Monoclonal Antibody Binding Sites of the Mouse Hepatitis Virus Receptor

Abstract

The attachment of Mouse Hepatitis Virus (MHV), a coronavirus, to its cellular receptor on the host cell membrane is the first step leading to viral infection. The best characterized receptor for MHV is a 120 kDa glycoprotein encoded by the biliary glycoprotein (Bgp) la gene. Other murine Bgp glycoproteins also serve as receptors for MHV but with less efficiency. Bgps belong to the carcinoembryonic antigen family which, in turn, belongs to the immunoglobulin superfamily. Chimeric glycoproteinsand recombinant mutated receptor proteins were generated to identify the sites on the receptor that binds to the Mouse Hepatitis Virus strain AS9 (MHV-AS9).

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Document Details

Document Type
Technical Report
Publication Date
Oct 16, 1995
Accession Number
AD1011463

Entities

People

  • Paul C. Shick

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Amino Acids
  • Biomedical And Dental Materials
  • Biotechnology
  • Blood
  • Caudovirales
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Copyrights
  • Materials
  • Polymeric Films
  • Recombinant Proteins
  • Viruses

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular Biology and Genetics