Mechanisms of Synaptic Alterations in a Neuroinflammation Model of Autism

Abstract

Here we investigated how Maternal Immune Activation (MIA), a risk factor for autism spectrum disorders (ASD) affects the development of synapses. The central hypothesis is that altered expression of cytokines and chemokines in the brain results in impaired synaptic development and altered behavior. We employed the MIA mouse model and so far found that in offspring there is a reduction in the number of synaptic structures in vivo as well as reduced motility. Behavioral impairments relevant to ASD are also reported.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1011465

Entities

People

  • Anna Dunaevsky
  • Ming Li

Organizations

  • University of Nebraska Medical Center

Tags

DTIC Thesaurus Topics

  • Autism
  • Blood
  • Brain
  • Cell Physiological Processes
  • Cells
  • Cytokines
  • Diseases And Disorders
  • Health Services
  • Mental Disorders
  • Neurodevelopmental Disorders
  • Neuroglia
  • Neurons
  • Neurosciences
  • Proteins
  • Risk Factors
  • Rodents
  • Three Dimensional

Fields of Study

  • Psychology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Immunology and Pathology
  • Neuroscience