Magnesium Sulfate and Betamethasone Reduce NUR77 Expression in a Preterm Labor Mouse Model

Abstract

Women in preterm labor are commonly treated with magnesium sulfate (MgSO4) and betamethasone (BMTZ) to reduce complications of prematurity including neurologic injury. MgSO4, however, prevents cerebral palsy in only 1 in 40 women who receive it. Understanding the cellular responses to MgSO4/BMTZ could allow for more effective treatments. Nur77 is a nuclear receptor implicated in apoptosis and immune responses- processes that occur in neuroinflammation. Our objective was to investigate if Nur77 is increased in the setting of inflammation-induced preterm labor and determine the impact of MgSO4 and BMTZ treatments.

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Document Details

Document Type
Technical Report
Publication Date
Jun 29, 2016
Accession Number
AD1011486

Entities

People

  • Andrew S Thagard
  • Danielle L. Ippolito
  • Monica A Lutgendorf
  • Nicholas Ieronimakis
  • Peter G. Napolitano

Organizations

  • Madigan Army Medical Center

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Cerebral Palsy
  • Inflammation
  • Magnesium
  • Magnesium Compounds

Fields of Study

  • Medicine

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