The Differential Expression of Calcitonin Gene Related Peptide, alpha CGRP mRNA, Choline Acetyltransferase, and Low Affinity Nerve Growth Factor Receptor in Cranial Motoneurons After Hypoglossal Nerve Injury During Postnatal Development

Abstract

This study examined the temporal expression of calcitonin gene-related peptide (CGRP), choline acetyltransferase (ChAT), and low-affinity nerve growth factor receptor (LNGFR) in hypoglossal motoneurons during postnatal development and after hypoglossal nerve injury. CGRP is aputative neurotrophic factor that coexists with acetylcholine, the neurotransmitter present in hypoglossal motoneurons. ChAT is a key enzyme involved in the synthesis of acetylcholine and is a specific marker for cholinergic neurons. Hypoglossal motoneurons transiently express LNGFR.

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Document Details

Document Type
Technical Report
Publication Date
Aug 21, 1996
Accession Number
AD1011501

Entities

People

  • Kristen M. Blake-bruzzini

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Autonomic Nervous System
  • Brain
  • Cells
  • Chemistry
  • Growth Factors
  • Nervous System
  • Neuroglia
  • Neurons
  • Neurosciences
  • Peptide Growth Factors
  • Peptides
  • Peripheral Nervous System
  • Surgery
  • Synapses

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Neuroscience