Sex Differences and the Effects of Stress on Subsequent Opioid Consumption in Adult Rats Following Adolescent Nicotine Exposure: A Psychopharmacologic Examination of the Gateway Hypothesis

Abstract

The present experiment examined effects of nicotine administration during adolescence on subsequent opioid consumption in male and female rats. Forty-one day old rats received saline (n =40), 6 mg nicotine/kg/day (n = 40), or 12 mg nicotine/kg/day (n = 40) by osmotic minipump for 24 hours/day for 19 days. After a 7-day cessation period, consumption of fentanyl-HCI solution was evaluated for 4 weeks. Throughout the opioid consumption phase, rats received either 20 minutes of immobilization stress (n = 60) or no-stress (n = 60) prior to opioid availability. Body weight, food, and water consumption were evaluated throughout the experiment.

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Document Details

Document Type
Technical Report
Publication Date
Jul 18, 1997
Accession Number
AD1011651

Entities

People

  • Laura C. Klein

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Brain
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Drug Abuse
  • Drug Addiction
  • Health Services
  • Human Behavior
  • Medical Personnel
  • Opioids
  • Pharmacology
  • Psychotropic Drugs

Fields of Study

  • Biology
  • Psychology

Readers

  • Gender and Food Studies
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Toxicology/Environmental Toxicology