CDCA7L and Mechanisms of Increased Male Bias in Glioma

Abstract

We are proposing to study CDCA7L in an NF1 mutant model of astrocytoma and glioblastoma and neurotransmitter levels in NF1 mutant brains, comparing males and females. The results of this work can be used to develop additional hypotheses on whether a yin-yang relationship exists in males and females between risk for brain cancer and risk for depression, or other learning and social dysfunctions. Developing new treatments for gliomas and learning/social dysfunction through a better understanding of the basic biology will benefit both male and female NF1 patients in the long term.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2016
Accession Number
AD1011669

Entities

People

  • Karlyne Reilly

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Catecholamines
  • Cell Line
  • Cells
  • Department Of Defense
  • Depression
  • Diseases And Disorders
  • Employment
  • Engineering
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Personnel Management
  • Phenotypes
  • Prejudice
  • Professional Development
  • Transcription Factors

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Molecular and Cellular Biology
  • Oncology