Operation Brain Trauma Therapy Extended Studies
Abstract
Operation brain trauma therapy (OBTT) and the related OBTT-extended studies (OBTT-ES) programsrepresent a multi-center therapy and biomarker screening consortium for the field of traumatic braininjury (TBI). OBTT uses there established models of TBI (Fluid percussion, controlled cortical impact(CCI), and penetrating ballistic-like brain injury) in rats for screening of therapies and evaluationof two biomarkers (glial fibrillary acidic protein [GFAP] and ubiquitin carboxyl-terminal esterase L1[UCH-L1]) at three different sites (University of Pittsburgh, University of Miami, and WRAIR).Biomarker assessment and interpretation are carried out at Banyan biomarkers, LLC, the University of Florida, and Messina University. OBTT has screened or is currently in screening or protocoloptimization on 10 drugs, including nicotinamide, erythropoietin, cyclosporine, simvastatin,levetiracetam, glibenclamide, kollidon VA64, amantadine, and minocycline. Approximately 2000 rats havebeen studied and >5000 biomarker levels to date. Thus far, of the 8 drugs that have completed testing,levetiracetam has shown significant benefit in two models while glibenclamide has shown benefit in CCI.GFAP has performed well including reproducibility, correlations to outcomes, and theranostic utility.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2015
- Accession Number
- AD1011694
Entities
People
- Patrick M. Kochanek
Organizations
- University of Pittsburgh