Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis

Abstract

We have evidence for the existence of a structure called tumor microenvironment of metastasis or TMEM, which is composed by a proangiogenic macrophage a, a Mena overexpressing tumor cell and an endothelial cell where the three cell complex is in direct contact with a blood vessel wall. We detected primary tumor TMEM (P-TMEM) in pre-malignant lesions. The P-TMEM is required to support early dissemination of pre- malignant neoplastic cells (early DTCs). We further hypothesize that after extravasation at secondary site TMEM (STMEM),in order to exit dormancy a stable S-TMEM structure needs to be maintained and that early DTCs cannot sustain its assembly possibly because they lack a persistent proangiogenic M recruiting program. Our rationale is that by understanding early dissemination and dormancy of DTCs we will find ways to eradicate dormant DTCs and prevent metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1011714

Entities

People

  • John Condeelis
  • Julio Aguirre-Ghiso

Organizations

  • Albert Einstein College of Medicine

Tags

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Blood
  • Blood Vessels
  • Bone Marrow
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Movement
  • Cells
  • Confocal Microscopy
  • Endothelial Cells
  • Epithelial Cells
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Stem Cells

Readers

  • Data Mining and Knowledge Discovery.
  • Molecular Biology and Genetics