In Vitro Determination of Bicarbonate Dosage to Alkalinize Local Anesthetics to Physiologic pH

Abstract

The addition of sodium bicarbonate to local anesthetic solutions immediately prior to their administration has been advocated as a method to reduce latency and prolong duration of regional blockade. The purpose of this study was to determine the appropriate dosages of sodium bicarbonate required to elevate the pH of local anesthetic solutions to physiologic pH (approximately 7.4), while maximizing time to precipitation formation. This descriptive study investigated the alkalinization of four local anesthetic solutions (Lidocaine, Mepivacaine, Bupivacaine, and Chloroprocaine-HCL) before and after freshly added epinephrine.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1997
Accession Number
AD1011753

Entities

People

  • Karen M. Strand

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Analgesia
  • Anesthesia
  • Anesthesia And Analgesia
  • Anesthesiology
  • Anesthetics
  • Buffers (Chemistry)
  • Chemical Reactions
  • Drug Abuse
  • Health Services
  • Hospitals
  • Hydrophilic Properties
  • Local Anesthetics
  • Nerve Fibers
  • Peripheral Nervous System
  • Ph Meters
  • Therapy

Readers

  • Cardiovascular Physiology