The Effects of Low Density Lipoproteins on Endothelial Mediated Vasoactivity in the Coronary Circulation in Swine

Abstract

Hypercholesterolemia. which includes high concentrations of low densitylipoproteins (LDL), alters normal endothelial function in patients with atherosclerosis. The aim of this study was to investigate the effects of low density lipoproteins on endothelialmediated changes in coronary blood flow and co!onary vascular resistance in hypercholesterolemic swine. Animals were assigned at random into three groups(n=5/group). A control group received normoIipic diet and a hyperlipidemic group received a lipid-enhanced diet. The third group received the lipid-enhanced diet as well a surgical procedure to induce mechanical damage in the left anterior descending coronary artery.

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Document Details

Document Type
Technical Report
Publication Date
Mar 27, 1998
Accession Number
AD1011772

Entities

People

  • Mark S. Crago

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cardiology
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular Surgery
  • Cardiovascular System
  • Cells
  • Chemistry
  • Health Services
  • Heart
  • Myocardial Ischemia
  • Vascular Endothelium
  • Veins

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.
  • Toxicology/Environmental Toxicology