Low Volume Resuscitation with Cell Impermeants

Abstract

Shock induces loss of energy dependent volume control mechanisms, which cause cell and tissue swelling, compression of capillaries, and impairment of microcirculatory O2 transfer. The objective of the study was to increase the tolerance to the low volume state by passively moving water from the cell back into the microcirculation by loading patients with specialized cell impermeant agents. This decompresses and reloads the capillaries, and increases the efficiency of low volume oxygen transfer. Rats or Pigs were hemorrhaged in lactate controlled models and given various impermeant based low volume resuscitated (LVR) solutions. Outcomes were determined by cardiovascular, metabolic, and tolerance endpoints.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2016
Accession Number
AD1011903

Entities

People

  • Martin J Mangino

Organizations

  • Virginia Commonwealth University

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cellular Structures
  • Chemistry
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel

Readers

  • Cardiovascular Physiology
  • Electrical Engineering