Nicotine-Induced Antinociception in Male and Female Sprague-Dawley Rats

Abstract

Nicotine is a key pharmacologically-active ingredient in tobacco that has cognitive and behavioral effects, including antinociception. The present research examined effects of nicotine as an anti-nociceptive agent in male and female Sprague-Dawley rats. Nicotine was administered subcutaneously (SC) to 145 male and female Sprague-Dawley rats. Behavioral measures of nociception included tail-flick, hot-plate, and cold-flick. The Formalin test, a model for persistent pain, was used to examine nicotine-induced antinociception. After antinociceptive testing, animals were sacrificed and blood was collected and assayed for plasma 17-(3-estradiol (in females). testosterone (in males), plasma nicotine and cotinine brain and spinal cord nicotine and cotinine levels.

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Document Details

Document Type
Technical Report
Publication Date
Jul 21, 1999
Accession Number
AD1012097

Entities

People

  • Nathaniel M. Apatov

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Brain
  • Chemistry
  • Drug Abuse
  • Health Services
  • Medical Personnel
  • Neurosciences
  • Pain
  • Pharmacies
  • Pharmacology

Fields of Study

  • Biology
  • Psychology

Readers

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