Biomarkers for Taxane Sensitivity and Hormonal Resistance in Patients with Castration Resistant Prostate Cancer

Abstract

This is the final report for a one year Hypothesis Development award initially accepted for funding 1/4/2013. Because of sequestration and delays in approvals between UW and DOD, the award was initiated 2/1/2014. The objective of this project was to utilize the presence of splice variant androgen receptor (AR) in circulating tumor cells (CTC) or disseminated tumor cells (DTC) to predict sensitivity to chemotherapy (docetaxel). Progress: Aims 1 and 2 are complete. Please see the detailed report for information regarding the presence of new types of AR splice variants detected in metastasis biopsies and the comparisons of detection AR splice variants in CTC, DTC and metastasis biopsies.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2016
Accession Number
AD1012225

Entities

People

  • Colm Morrissey
  • Robert B. Montgomery
  • Stephen R Plymate

Organizations

  • University of Washington

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Androgen Receptors
  • Androgens
  • Biological Markers
  • Biomedical Research
  • Cancer
  • Castration
  • Chemotherapy
  • Department Of Defense
  • Detection
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Resistance
  • Sensitivity
  • Therapy

Readers

  • Government Contracting/Procurement.
  • Prostate Cancer Biology.