The Role of Sex and Strain in Behavioral and Biologic Stress Responses of Rats

Abstract

Stress has been implicated in the etiology of many behavioral disorders (Le., drug abuse, feeding disorders) and disease states (i.e., hypertension, diabetes, depression). Individuals differ, however, in vulnerability to stress related disease. The goal of this doctoral research was to identify potential behavioral and possibly biochemical markers of stress vulnerability vs. resilience in male and female rats of two strains (Sprague-Dawley and Long-Evans) that might predict eventual development of specific stress-related behavioral disorders or diseases in certain subgroups of humans. The experiment assessed the effects of mild, repeated daily stress on multiple behaviors and biochemical indices within the same subjects to construct a detailed model of potential markers of stress vulnerability vs. resilience.

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Document Details

Document Type
Technical Report
Publication Date
Apr 07, 2000
Accession Number
AD1012287

Entities

People

  • Martha M. Faraday

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Body Weight
  • Brain
  • Chemical Synthesis
  • Chemistry
  • Cognition
  • Health Services
  • Human Behavior
  • Medical Personnel
  • Psychology

Fields of Study

  • Biology
  • Psychology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Toxicology/Environmental Toxicology