Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury

Abstract

Traumatic brain injury (TBI) is characterized by neuroinflammation and oxidative stress as well as impaired neurocognitive function Our studies have revealed protective effects of endocannabinoid (EC) degradation inhibitors administered systemically 30 min post-TBI. We show marked suppression of astrocyte and microglia activation, improved neurobehavioral function, attenuation of blood brain barrier leak, and decreased glutamatergic excitability. These findings indicate that EC degradation inhibition post-TBI is neuroprotective.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2016
Accession Number
AD1012567

Entities

People

  • Patricia E. Molina

Organizations

  • LSU Health Sciences Center New Orleans

Tags

Communities of Interest

  • Energy and Power Technologies
  • Human Systems
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Blood
  • Blood-Brain Barrier
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Cerebral Edema
  • Chemistry
  • Cognitive Impairment
  • Craniocerebral Trauma
  • Drug Abuse
  • Fatty Acids
  • Neurodegeneration
  • Neuroglia
  • Proteins
  • Wounds And Injuries

Fields of Study

  • Medicine
  • Psychology

Readers

  • Immunology and Pathology
  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.