Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse

Abstract

Studies relating to the role autophagy in tumor dormancy revealed that transient inhibition of autophagy during ADR treatment resulted in prolonging tumor dormancy. However, complete knockdown of autophagy gene expedited tumor relapse. We also identified two distinct types of ADRinduced tumor dormancy including Ki67 /low indolent and Ki67 quiescent tumor dormancy. Whereas that former was sensitive to immunoediting, escape and relapse, the latter was found to be resistant to tumor immunoediting and escape. Adoptive immunotherapy (AIT) was also found to support regression of ADRinduced dormant tumor cells.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2016
Accession Number
AD1012572

Entities

People

  • Masoud H Manjili

Organizations

  • Virginia Commonwealth University

Tags

DTIC Thesaurus Topics

  • Autophagy
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Immunomodulation
  • Immunotherapy
  • Lymphatic Diseases
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Papillomavirus Infections
  • Students
  • Therapy
  • Vaccines

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Data Mining and Knowledge Discovery.
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech