Comparison of Hydroxocobalamin Versus Norepinephrine Versus Saline in a Swine Model of Severe Septic Shock

Abstract

Sepsis is associated with a mortality of nearly 30%. Mortality is due, in part, to an uncontrolled inflammatory response. Matrix metalloproteinase-9 (MMP-9) and heat shock protein 70 (HSP 70) have been suggested to be biomarkers of severe sepsis and may be useful indicators of treatment success. Hydroxocobalamin (HOC), which regulates inducible nitric oxide synthase and increases systemic vascular resistance, may be effective in treating sepsis-induced hypotension and reversing overexpression of inducible nitric oxide synthase. Objective: To compare efficacy of HOC versus norepinephrine (NOR) versus saline in swine with lipopolysaccharide (LPS)-induced endotoxemia.

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Document Details

Document Type
Technical Report
Publication Date
May 18, 2016
Accession Number
AD1012605

Entities

People

  • Joseph K Maddry
  • Maria G. Castaneda
  • Normalynn Garrett
  • Susan M. Boudreau
  • Vikhyat S Bebarta

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Animals
  • Arteries
  • Biomedical Research
  • Digital Information
  • Education
  • Hemorrhagic Shock
  • Infusions
  • Intellectual Property
  • Laboratory Animals
  • Lightning
  • Materials
  • Norepinephrine
  • Sepsis
  • Technical Information Centers

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.